Open Access Brigelius-Floh R. Adverse effects of vitamin E by induction of drug metabolism. b, Viability of control and SLC7A11 KO U251 cells treated with 12M of sodium selenite for 48hr. wrote the manuscript with consultation from all of the authors. d, Map of wild type SEPHS2 and CRISPR resistant mutant SEPHS2_U60C. Aykin-Burns N., Ahmad I.M., Zhu Y., Oberley L.W., Spitz D.R. Potent ferroptosis inhibitors, such as ferrostatin-1 (Fer-1) and deferoxamine (DFO), rescue cells from SS-induced ferroptosis. For b-h, n=3 biological replicates; error bars are S.D. Gilbert AK, Newton TD, Hettiaratchi MH, Pluth MD. Demasi M., Penatti C.A.A., Delucia R., Bechara E.J.H. Schecter, A., Shanske, W., Stenzler, A., Quintilian, H. & Steinberg, H. Acute hydrogen selenide inhalation. The increased mortality associated with high dose vitamin E may be primarily as a result of cardiometabolic effects. Othman A.I., El-Missiry M.A., Amer M.A., Arafa M. Melatonin controls oxidative stress and modulates iron, ferritin, and transferrin levels in adriamycin treated rats. Unable to load your collection due to an error, Unable to load your delegates due to an error. 4). Clipboard, Search History, and several other advanced features are temporarily unavailable. Thus, the inorganic Se compound, sodium selenite (SeL), due to its prooxidant character, represents a promising alternative for cancer therapy. ICP-MS-based experiments for selenite measurements were conducted by M.S. The solvent and treatment regimen of sodium selenite cause its effects to vary on the radiation response of human bronchial cells from tumour and normal tissues. For a,c,e and i, n=3 biological replicates; error bars are S.D. are listed as the authors on a patent application filed by University of Massachusetts Medical School on targeting SEPHS2 in cancer therapy, and on the methodology for hydrogen-selenide detection. Unauthorized use of these marks is strictly prohibited. 1 Study of Sodium Selenite in Banerjee, B. D., Dwivedi, S. & Singh, S. Acute hydrogen selenide gas poisoning admissions in one of the hospitals in Delhi, India: case report. Yan B., Stantic M., Zobalova R., Bezawork-Geleta A., Stapelberg M., Stursa J. Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner. c, SEPHS2 immunoblots from the cells used in b. A more specific agent for scanning tumors. Values are relative to the cells cultured in 100% growth media, set at 1.0. e, Immunoblot of FPS1 and catalase in SEPHS2 KO sensitive and in sensitive cell lines. Thus selenite is capable of oxidizing polythiols to corresponding disulfides, but does not react with monothiols. Jang Y., Rao X., Jiang Q. Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment. Girotti A. Mechanisms of lipid peroxidation. Vitamin E can outcompete the propagation reaction with a much higher rate constant (k8104M 1 s1) [96] to also form PLOOH while preventing further propagation. Ooki A, Dinalankara W, Marchionni L, Tsay JJ, Goparaju C, Maleki Z, Rom WN, Pass HI, Hoque MO. 8 Reactive oxygen species production by excess selenium, and implications in SEPHS2 KO toxicity. Defining normoxia, physoxia and hypoxia in tumours-implications for treatment response. In this paper, human cervical cancer HeLa cells were investigated by MTT assay and morphological observation to get appropriate selenite concentrations for proteomic study. Transketolase is a critical pentose phosphate pathway mediator necessary for regenerating NADPH. For e, n=3 biological replicates; error bars are S.D. Thus selenite (Se+4) can undergo redox reaction, for example with protein's sulfhydryl groups expressed on the surface of tumor cells. Epub 2006 Jan 23. Side chain moieties of individual tocopherols and tocotrienols. Oncol. Breast cancer cells (4T1, MCF-7) and noncancer cells (NIH/3T3, HEK293) were exposed to different concentrations of Chest 77, 554555 (1980). The population model described Cavalieri, R. R., Scott, K. G. & Sairenji, E. Selenite (75Se) as a tumor-localizing agent in man. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. 4). WebThioredoxin reductase activity is increased by sodium selenite in DU-145 prostate cancer cells. The second pathway abstracts a hydrogen atom of another phospholipid to form PLOOH. Inhibition and Removal of Mature Mixed-Bacteria Biofilms on Voice Prostheses by Sodium Selenite. Given the prooxidant-propelled metabolic alterations in cancer cells, relative to normal cells, we hypothesize that redox active small molecules that can selectively act as pro-oxidants in cancer cells may provide a novel, biochemical adjuvant to cancer therapy while simultaneously protecting normal tissues by functioning in an antioxidant capacity. Wang, T., Wei, J. J., Sabatini, D. M. & Lander, E. S. Genetic screens in human cells using the CRISPRCas9 system. Sodium selenite is often given to moderate the side effects of cancer therapy to enhance the cellular defence of non-cancerous cells. Nucleic Acids Res. Chin Med J (Engl). Persistent accumulation of sphingolipids in cancer cells is known to induce apoptosis and inhibit cell growth [[132], [133], [134]]. Selective modulation of the therapeutic efficacy of anticancer drugs by selenium containing compounds against human tumor xenografts. However, the underlying molecular mechanisms governing SS-mediated repression of lung cancer stem cells remain largely undefined. Cancer Discov. Res. Med Hypotheses. Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase with activity changes in both enzymes. The X-axis and y-axis of Flow cytometry density plots were designated as Annexin V-FITC and PI, respectively. From each of these studies, the authors concluded that melatonin reduced the risk of death at 1 year (relative risk=0.66, 95% confidence interval: 0.590.73) with no severe adverse events. Physiological concentrations of melatonin have been shown to decrease the growth rate of breast cancer cells by increased expression of p21/WAF1 along with p53 [34]. J. Bacteriol. GPx4 detoxifies PLOOH and converts it to its corresponding alcohol while GPx1 reacts with both H2O2 and ROOH to form either H2O or ROH. and D.K. Low GPx4 activity can be caused by selenium deficiency, which can be overcome by supplementation of Se [99]. Rodogna et al. Molecules. However, this activity also becomes a liability for cancer cells because selenide is poisonous and must be processed by SEPHS2. Sodium selenite acts by depleting enzymes that protect against cellular oxidative stress. f, Micrographs of serial human tumor sections stained with CD31 antibody and in situ hybridized with SEPHS2 RNA probe, showing vasculature. All reported effects were independent of cancer type and no severe adverse events associated with melatonin were reported. Sodium Selenite WebSodium selenite administration resulted in significant increase in percentage of apoptotic lymphoma cells after therapy in group II (78.9 +/- 13.3% versus 58.9 +/- 18.9%, p < 0.05). 2006 Mar 10;160(1):1-40. doi: 10.1016/j.cbi.2005.12.009. The combination treatment led to a reduction in the survival of cells (Figure. Sci.). Transketolase counteracts oxidative stress to drive cancer development. Zetner D., Andersen L., Rosenberg J. Pharmacokinetics of alternative administration routes of melatonin: a systematic review. f, Scanned image of a polystyrene microplate cover with PVP spots embedded with silver nitrate or lead acetate. Selenium Biofortification: Roles, Mechanisms, Responses and Prospects. Warburg O., Wind F., Negelein E. The metabolism OF tumors IN the body. Would you like email updates of new search results? Methods 11, 783784 (2014). Hirata H., Ladenheim B., Rothman R.B., Epstein C., Cadet J.L. 1 A) and sodium selenite ( Fig. Following an oral dose of 200mg, the plasma ascorbate concentration reaches 80M [[208], [209]]. Treatment with high amount of sodium selenite selectively eliminates cancer cells by generating more free radicals than that of normal cells without a systemic Se toxicity . Chen W., Hill H., Christie A., Kim M.S., Holloman E., Pavia-Jimenez A. The chemotherapy agent, adriamycin, is associated with significant heart and liver toxicity via oxidative damage. Reduction of postoperative lymphedema after oral tumor surgery with sodium selenite. Values are relative to the cell lines expressing nontargeting (CTRL) guide, set at 1.0. Free radicals, metals and antioxidants in oxidative stress-induced cancer. The primary side effect reported with 1g given intravenously was drowsiness, usually at the beginning of the treatment [16]. and A.P. Selenite, a representative inorganic form of selenium, is preferentially accumulated in tumors. WebSodium selenite (SS) affects cancer cells cultured as multicellular tumor spheroids (MCTS or 3D). WebWe show that sodium selenite inhibits the growth and proliferation of colon cancer cells in a time- and dose-dependent manner, with HCT-116 cells being more sensitive than HCT-116-p53KO cells. Federal government websites often end in .gov or .mil. These elevations correlated with a decrease in liver and heart glutathione and glutathione-S-transferase activity, along with increases in lipid peroxidation, protein oxidation, catalase activity, and glutathione peroxidase activity. sharing sensitive information, make sure youre on a federal injected sodium selenite in a mouse model of peritoneal cancer with an emphasis on understanding the mechanism of action of selenite. Bookshelf Accessibility Breast cancer and circadian disruption from electric lighting in the modern world. We thank M. Green, E. Baehrecke, A. Mercurio, D. Sabatini, C. Haynes, D. Guertin, B. Bible, K. Krupczak, K. Luk, C. Brown, A. Jaferi and S. Deibler for advice, assistance and feedback. Miller E., Pastor-Barriuso R., Dalal D., Riemersma R., Appel L., Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy. In addition to its ability to act as a free radical scavenger, melatonin may also chemically react with redox active metals contained within the cell to blunt the catalysis of oxidation reactions (e.g. 2010 Dec;84(12):919-38. doi: 10.1007/s00204-010-0595-8. Also in 2014, a phase 1 clinical trial in ovarian cancer showed that pharmacological ascorbate enhanced chemosensitivity in murine models and protected against carboplatin and paclitaxel chemotherapy-associated toxicity in human subjects [215]. Across multiple tumor cell lines, the ED50 of pharmacological ascorbate is directly correlated with intracellular catalase activity, whereas catalase inhibition with 3-amino-1,2,4-triazole enhanced ascorbate cancer cell killing [195]. Oral doses of melatonin ranging from 20 to 40mg given daily, gradually throughout the day, have been well tolerated [[70], [71], [72]]. Karbownik M., Reiter R.J., Burkhardt S., Gitto E., Tan D.-X., Lewiski A. Melatonin attenuates estradiol-induced oxidative damage to DNA: relevance for cancer prevention. The residual vitamin E radical (TO) is then recycled by vitamin C via a water-lipid interface interaction [94,97,98]. Jiang Q., Wong J., Fyrst H., Saba J.D., Ames B.N. In prospective clinical trials, oral melatonin has been shown to enhance the effectiveness of traditional chemotherapy approaches, such as cisplatin and etoposide [80], tamoxifen [81], and irinotecan [82]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Another study, its results published in 2006, monitored 29,361 men for up to 8 years and found no evidence that vitamin C supplementation reduced the incidence of prostate cancer [187]. Light exposure at adverse times can disrupt circadian rhythms and may contribute to the development, promotion, and progression of cancer [31]. Sodium Selenite Consequently, macrophages of the lymphatic system do not recognize neoplastic cells as 'foreign' bodies and spare them from the immune destruction. Lee D.J., Kang D.H., Choi M., Choi Y.J., Lee J.Y., Park J.H. Morphol. WebIn this study, for the first time, we demonstrate that sodium selenite (SS), a well-established redox-active selenium compound, is a novel inducer of ferroptosis in a variety of human cancer cells. Therefore, the synergy of vitamin E and selenium are thought to be novel partners that can prevent these free radical-mediated oxidations that could lead to cancer or be used in the treatment of cancer. 2021 Apr 6;10(7):1540. doi: 10.3390/jcm10071540. A recent phase I clinical trial of newly diagnosed glioblastoma patients assessed the potential efficacy of pharmacological ascorbate with radiation and temozolomide [216]. volume2,pages 603611 (2020)Cite this article. conceived the project; A.E.C., N.L. Burns J.J. Sodium Selenite Enhanced the Anti-proliferative Effect Serum levels of IGF-1 were decreased by the combination therapy. Lipid peroxidation chain reactions can be initiated by 1-electron oxidants (Fig. In the present study, we fed intestinal cancer mouse model Muc2/p21 double mutant mice with a selenium-enriched (sodium selenite) diet for 12 weeks or 24 weeks, Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats. Extended Data Fig. Sodium selenite is often given to moderate the side effects of cancer therapy to enhance the cellular defence of non-cancerous cells. Epub 2021 Sep 6. eCollection 2020. Each value was normalized to that of unconditioned medium. f, Viability of U251 cells treated with vehicle, 12M sodium selenite, and/or 10M Erastin for 72hr. Supplemental and dietary vitamin E, -carotene, and vitamin C intakes and prostate cancer risk. However, these studies we not stratified according to circulating levels of ascorbate and therefor might not reflect what supplementation would do in a setting where the subjects were deficient. Mol. [Modulation of the inflammatory response through complement-neutrophil activation feedback mechanism with selenium and vitamin E]. Melatonin has been shown to mitigate the activity of the heme containing protein, myeloperoxidase [27]. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. In the 1970s, the potential utility of supraphysiological doses of ascorbate (pharmacological ascorbate; achieving mM plasma ascorbate concentrations) given intravenously was established in multiple trials that showed the safety and efficacy of the treatment with various terminal cancer patients [[202], [203], [204], [205]]. Results: Since then, more studies have come out suggesting that the RDA should be increased to 75 mcg/d. Besides biological effects in reducing excessive production of ROS, sodium selenite also displays various pharmacological effects. Neurotoxins: free radical mechanisms and melatonin protection. 28, 2730 (2000). The mechanism of sodium selenite interaction with sulfhydryl groups (SH) of the cell membrane is explained in the following equation [ 3 ]: a, Expression profiles of SEPHS2 in 28 types of normal and tumor tissues. The oxidants formed by the oxidation of pharmacological ascorbate can facilitate the release of even more iron into the labile iron from iron sulfur cluster-containing proteins (e.g, aconitase). Pharmacotherapy, for example with diuretics, has received little attention, because they were not effective and only offered short-term solutions. These exciting observations suggest that in addition to sensitizing cancer cells to radiation and chemotherapy, pharmacological ascorbate may also ameliorate radiation-induced side effects. Counts are from random fields. Sevanian A., Kim E. Phospholiphase A2 dependent release of fatty acids from peroxidized membranes. Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide. Assoc. Nature 575, 688692 (2019). Free Radic. Both ramelteon and agomelatine are promising because they have greater bioavailability than melatonin itself [48]. Selenite Clinical applications of HPLC-ICP-MS element speciation: A review. Drug: sodium selenite: Phase 2: Study Design. In the present study, we examined sodium selenite-induced oxidative stress and apoptosis in a human hepatoma cell line (HepG 2).Sodium selenite (10 M) exerted clear cytotoxic effect, as shown by the significant increase of lactate Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models. Abstract. The definitive role of the ETC disruptions by melatonin has yet to be elucidated but shows great promise since it is well known that cancer cells have significantly elevated levels of ROS relative to normal cells [3,5,40]. Sodium Selenite Accentuates the Therapeutic Effect of - Hindawi For therapeutic purposes, the dose for sodium selenite ranges from 6,000-30,000 micrograms per day. An extensive overview on selenium compounds for cancer treatment are provided in Ref. Cancer Tocotrienols may also protect normal tissues from radiation-induced damage. g, Immunoblots of GPX4, SEPHS2 and Hif1a in MDAMB231 cells subjected to hypoxia (1% O2) for 48hrs. Nature Metabolism Rautalahti M., Virtamo J., Taylor P., Heinonen O., Albanes D., Haukka J. Decreased expression of p90 RSK indicated that sodium selenite down-regulated ERK signaling in thyroid cancer cells. Liou G.-Y., Storz P. Reactive oxygen species in cancer. https://journals.lww.com/eurjcancerprev/Fulltext/2014/07000/Light_exposure_at_night,_sleep_duration,.6.aspx, http://europepmc.org/abstract/MED/32414091, http://europepmc.org/abstract/MED/30513765, Dietary supplement: 1000mg vitamin E for 7 weeks, Dietary supplement: vitamin E -tocotrienol supplied as 100mg, 200mg, and 400mg capsules, Dietary supplement: tocotrienol 200mg twice a day, Intravenous high dose ascorbate (75g) in combination with radiotherapy, Intravenous high dose ascorbate (75g) in combination with radiation and chemotherapy, Dietary Supplement: Oral ascorbate in combination with chemotherapy, Intravenous ascorbate in combination with chemotherapy, Intravenous ascorbate (87.5g) in combination with radiation and chemotherapy, Oral selenomethionine (4mg) in combination with axitinib (5mg), Significantly increased 1-year survival rate of patients, melatonin (20mg/day) orally starting 7 days before tamoxifen. Chen Q., Espey M.G., Sun A.Y., Lee J.-H., Krishna M.C., Shacter E. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Biochim. In the present study, glutathione was demonstrated to play a dual role on selenite (Se)-induced oxidative stress and apoptosis in human hepatoma HepG (2) cells. In 2005, a randomized, double-blind, placebo-controlled trial evaluating the effects of high dose vitamin E supplementation (400mg daily) on patients at risk for cardiovascular disease was completed [147]. c, Viability of U251 cells overexpressing vector or CAT treated with vehicle or H2O2 for 48hr. 2021 Mar;10(3):1599-1602. doi: 10.21037/tcr-20-3143. Sodium selenate: A potential future treatment for early-onset The biochemical anticancer pro-oxidant effects of vitamin E have been extensively studied and are thought to be mediated by tocopheroxyl/tocotrienal-radical formation from mitochondrial metabolism in cancer cells [89,90,[117], [118], [119]]. Peroxiredoxin-2 represses melanoma metastasis by increasing E-cadherin/-catenin complexes in adherens junctions. In addition, patients with multiple tumor types were enrolled in a Phase one trial: the SECAR study, in which 34 patients with different resistant tumor types received i.v. official website and that any information you provide is encrypted 18 October 2022, npj Science of Food Epub 2011 Oct 20. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. Wada S., Satomi Y., Murakoshi M., Noguchi N., Yoshikawa T., Nishino H. Tumor suppressive effects of tocotrienol in vivo and in vitro. AscH acts as a reducing agent and donor antioxidant that can undergo two consecutive one-electron oxidations to produce the ascorbate radical (Asc-) and dehydroascorbic acid (DHA), respectively. HHS Vulnerability Disclosure, Help and P.L.G. Due to its apparent antioxidant capacity and potential to interact with catalytic metals, melatonin is currently being investigated as a supplement for both cancer prevention and treatment. Hirata H., Asanuma M., Cadet J. Melatonin attenuates methamphetamine-induced toxic effects on dopamine and serotonin terminals in mouse brain.

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